Gamila S.M. El-Saeed
National Research Centre, Egypt
Title: Relationship between Hepcidin, L-Carnitine, Anemia and Inflammation in Children of Hemodialysis
Biography
Biography: Gamila S.M. El-Saeed
Abstract
Background: The majority of studies on anemia, inflammation, and disturbances of iron metabolism have focused on patients in end-stage renal failure; this study aim was to investigate the relation ship between Carnitine and Hepcidin levels among the children of hemodialysis end stage renal disease (ESRD) and iron metabolism in them. Method: Thirty children with ESRD undergoing HD, and thirty healthy, age- and sex-matched children were included. Serum levels of iron, ferritin and total binding capacity (TIBC), hemoglobin, albumin (ALB) .Total L- Carnitine(LC), high-sensitivity C-reactive protein( hs CRP), hepcidin, were measured. Result: Abnormal serum inflammatory changes iron status and LC , were exhibited in HD children compared with healthy controls, Pearson’s correlation revealed a significant inverse correlation between hepcidin levels and ferritin, and positively with hsCRP and iron where serum albumin positively with hsCRP and ferritin , also a postive correlation found between LC and iron, ferritin.A multivariate regression analysis demonstrated a positive correlation between inflammatory risk marker hs CRP >3 mg/l) and hepcidin levels. Also a positive correlation was found between LC and iron levels. Conclusion: In children under hemodialysis, oral L-carnitine can increase serum albumin level and prevent CRP rising, beneficial effects of L-carnitine on anemia and, its supplementation is recommended for these patients. Malnutrition-inflammation complex is an incremental predictor in hemodialysis patients. Further studies are needed to assess whether modulating inflammatory or Nutritional processes can improve anemia management. Key words: Hepcidin ,L-Carnitine, Anemia, Inflammation ,Children, Hemodialysis.